Author: Mary E. Lynch Abstract Chronic pain is an escalating public health problem. Currently available treatments are inadequate to control chronic pain conditions, and there is a critical need for novel treatments. Over a half century of elegant preclinical research has Read More …
Category: Research
Efficacy and adverse effects of medical marijuana for chroni …
Authors: Deshpande A, Mailis-Gagnon A, Zoheiry N, Lakha SF. Abstract OBJECTIVE: To determine if medical marijuana provides pain relief for patients with chronic noncancer pain (CNCP) and to determine the therapeutic dose, adverse effects, and specific indications. DATA SOURCES: In April Read More …
Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in D …
Authors: Verty AN, Stefanidis A, McAinch AJ, Hryciw DH, Oldfield B. Abstract The cannabinoid receptor 2 (CB2) is well known for its immune modulatory role. However, recent localisation of CB2 receptors in metabolically active tissue suggests that the CB2 receptor plays Read More …
Controlled release tablet formulation containing natural Δ9 …
Authors: Punyamurthula NS, Hingorani T, Adelli G, Gul W, ElSohly MA, Repka MA, Majumdar S Abstract Cannabinoids are increasingly being used in the treatment of chemotherapy-induced nausea and vomiting (CINV) because of their action on thecannabinoid receptors, CB1 and CB2. The Read More …
GPR55 – a putative “type 3” cannabinoid re …
Authors: Yang H, Zhou J, Lehmann C. Abstract G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classicalcannabinoid receptors. The pharmacology of GPR55 is not yet fully elucidated; however, GPR55 utilizes Read More …
GPR55 – a putative “type 3” cannabinoid receptor in inflammation.
Authors: Yang H, Zhou J, Lehmann C. Abstract G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1 and CB2 receptors despite low homology with those classicalcannabinoid receptors. The pharmacology of GPR55 is not yet fully elucidated; however, GPR55 utilizes Read More …
Biased Type 1 Cannabinoid Receptor Signalling Influences Neu …
Author: Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. Abstract Huntington disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder with limited treatment
Cannabinoid Receptor-Specific Mechanisms To Ameliorate Pain …
Authors: Lucile Vincent, Derek Vang, Julia Nguyen, Barbara Benson, Jianxun Lei, Kalpna Gupta. Abstract Sickle cell anaemia is a manifestation of a single point mutation in haemoglobin, but inflammation and pain are the insignia of this disease which can start in Read More …
Cost-effectiveness of Sativex in multiple sclerosis spasticity: new data and application to Italy.
Authors Slof J, Ruiz L, Vila C. Abstract; Multiple sclerosis (MS) is a chronic progressive disease that carries a high socioeconomic burden. Spasticity (rigidity and spasms) is common in MS and contributes to MS-related disability. This study aims to evaluate the Read More …
Cost-effectiveness of Sativex in multiple sclerosis spastici …
Authors Slof J, Ruiz L, Vila C. Abstract; Multiple sclerosis (MS) is a chronic progressive disease that carries a high socioeconomic burden. Spasticity (rigidity and spasms) is common in MS and contributes to MS-related disability. This study aims to evaluate the Read More …