Home / Research / Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson’s disease

Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson’s disease

BACKGROUND AND PURPOSE Previous findings have indicated that a cannabinoid, such as Δ9-THCV, which has antioxidant properties and the ability to activate CB2 receptors but to block CB1, might be a promising therapy for alleviating symptoms and delaying neurodegeneration in Parkinson’s disease (PD).

EXPERIMENTAL APPROACH The ability of Δ9-THCV to reduce motor inhibition and provide neuroprotection was investigated in rats lesioned with 6-hydroxydopamine and in mice lesioned with lipopolysaccharide (LPS).

KEY RESULTS Acute administration of Δ9-THCV attenuated the motor inhibition caused by 6-hydroxydopamine, presumably through changes in glutamatergic transmission. Moreover, chronic administration of Δ9-THCV attenuated the loss of tyrosine hydroxylase–positive neurones caused by 6-hydroxydopamine in the substantia nigra, through an effect related to its antioxidant properties (it was reproduced by cannabidiol -enriched botanical extract). In addition, CB2 receptor–deficient mice responded to 6-hydroxydopamine in a similar manner to wild-type animals, and CB2 receptors were poorly up-regulated in the rat substantia nigra in response to 6-hydroxydopamine. By contrast, the substantia nigra of mice that had been injected with LPS exhibited a greater up-regulation of CB2 receptors. In these animals, Δ9-THCV also caused preservation of tyrosine hydroxylase–positive neurones. This effect probably involved CB2 receptors as it was also elicited by the selective CB2 receptor agonist, HU-308, and CB2 receptor–deficient mice were more vulnerable to LPS lesions.

CONCLUSIONS AND IMPLICATIONS Given its antioxidant properties and its ability to activate CB2 but to block CB1 receptors, Δ9-THCV has a promising pharmacological profile for delaying disease progression in PD and also for ameliorating parkinsonian symptoms.

Full text available for free at the British Journal of Pharmacology.

Authors: C García, C Palomo-Garo1, M García-Arencibia, JA Ramos, RG Pertwee, and J Fernández-Ruiz.

 

Top

WordPress database error: [Table './mcawaren_wp/wp_woocommerce_sessions' is marked as crashed and should be repaired]
INSERT INTO wp_woocommerce_sessions (`session_key`, `session_value`, `session_expiry`) VALUES ('ae5bc9ad0ba680dcbb31f5bd42a2b02d', 'a:7:{s:4:\"cart\";s:6:\"a:0:{}\";s:11:\"cart_totals\";s:367:\"a:15:{s:8:\"subtotal\";i:0;s:12:\"subtotal_tax\";i:0;s:14:\"shipping_total\";i:0;s:12:\"shipping_tax\";i:0;s:14:\"shipping_taxes\";a:0:{}s:14:\"discount_total\";i:0;s:12:\"discount_tax\";i:0;s:19:\"cart_contents_total\";i:0;s:17:\"cart_contents_tax\";i:0;s:19:\"cart_contents_taxes\";a:0:{}s:9:\"fee_total\";i:0;s:7:\"fee_tax\";i:0;s:9:\"fee_taxes\";a:0:{}s:5:\"total\";i:0;s:9:\"total_tax\";i:0;}\";s:15:\"applied_coupons\";s:6:\"a:0:{}\";s:22:\"coupon_discount_totals\";s:6:\"a:0:{}\";s:26:\"coupon_discount_tax_totals\";s:6:\"a:0:{}\";s:21:\"removed_cart_contents\";s:6:\"a:0:{}\";s:8:\"customer\";s:691:\"a:26:{s:2:\"id\";s:1:\"0\";s:13:\"date_modified\";s:0:\"\";s:8:\"postcode\";s:0:\"\";s:4:\"city\";s:0:\"\";s:9:\"address_1\";s:0:\"\";s:7:\"address\";s:0:\"\";s:9:\"address_2\";s:0:\"\";s:5:\"state\";s:2:\"MB\";s:7:\"country\";s:2:\"NZ\";s:17:\"shipping_postcode\";s:0:\"\";s:13:\"shipping_city\";s:0:\"\";s:18:\"shipping_address_1\";s:0:\"\";s:16:\"shipping_address\";s:0:\"\";s:18:\"shipping_address_2\";s:0:\"\";s:14:\"shipping_state\";s:2:\"MB\";s:16:\"shipping_country\";s:2:\"NZ\";s:13:\"is_vat_exempt\";s:0:\"\";s:19:\"calculated_shipping\";s:0:\"\";s:10:\"first_name\";s:0:\"\";s:9:\"last_name\";s:0:\"\";s:7:\"company\";s:0:\"\";s:5:\"phone\";s:0:\"\";s:5:\"email\";s:0:\"\";s:19:\"shipping_first_name\";s:0:\"\";s:18:\"shipping_last_name\";s:0:\"\";s:16:\"shipping_company\";s:0:\"\";}\";}', 1542800481) ON DUPLICATE KEY UPDATE `session_value` = VALUES(`session_value`), `session_expiry` = VALUES(`session_expiry`)